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DanLittman @ med.nyu.edu
| Description | : | SFB.
"Our guts are colonized by trillions of commensal microbiota, whose influence on our immune systems is just beginning to be appreciated. Altered colonization has been associated with diseases such as allergy and inflammatory bowel disease, suggesting that commensals may play an important role in regulating immune system responses; to what extent, however, is not yet understood. Gaboriau-Routhiau et al. have addressed this issue by comparing germ-free and normally colonized mice. They found that commensal microbiota were critical for maintaining T cell homeostasis in the gut. Germ-free mice exhibited altered gene expression profiles of cytokines and transcription factors that were associated with T helper cell–mediated immune responses. Recolonization with microbiota derived from mouse fecal matter restored normal expression patterns. Surprisingly, this effect was largely restricted to one strain of bacteria: the segmented filamentous bacteria (SFB)" www.ncbi.nlm.nih.gov/pubmed/19833089 GOTO NotYetUnderstood |
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